Through the national colon cancer screening initiative in France, medical professionals were only screening approximately 35% of the population due to both lack of participation and the exclusive guidelines established regarding the risk-level of patients tested. Only patients facing an average risk of colon cancer were included in this initiative, excluding high risk patients and requiring that they seek individual based screenings.

In order to compare alternative screening scenarios for INCa, we constructed a disease model of colon cancer, reproducing how colon cancer appears based on literature and a MISCAN model. This disease model is individual based, simulating each of the four million representative patients that we modeled separately. Utilizing the data produced in these models, we were able to illustrate how we expected colon cancer to appear in patients, and thereby gather insight on the overall cost and epidemiology of colon cancer in France.

Additionally, we performed a cost-effectiveness analysis of the various alternative screening scenarios in comparison to the current initiative.

Finally, we utilized this model to assess the benefits of the current initiative in place. In doing this, we were able to determine that the initiative is effective in reducing colon cancer incidence and mortality, even at the current screening rate.