While voluntary individual screening for cervical cancer is already well established in France, the country will soon begin to implement organised screening with ambitious screening rates and cervical cancer incidence reduction goals in mind. We developed a micro-simulation model to identify the most efficient screening modalities combination that will allow medical professionals to accomplish these objectives.

The French National Institute of Cancer (INCa) conducted this project in collaboration with an highly qualified board of clinical experts and stakeholder representatives (French national health insurance, ministry of health, patients and professionals). They used a pragmatic approach to implement a model that accurately reflects the reality and how each scenario will impact the screening landscape. Practical issues, including feasibility, new and upcoming screening technologies, the role of HPV-vaccination, social disparities and the impact of screening tests generalization on costs, were considered in the study.

We compared organized screening scenarios, combining all relevant screening modalities, to determine their impact on practices, cervical cancer epidemiology and cost-effectiveness.